James Preston Wayne
- Born: 10 May 1870, , Calhoun County, West Virginia
- Marriage (1): Mary Davis on 1 Aug 1892 in , Clay County, West Virginia
- Marriage (2): Vinita Hathaway on 25 May 1907
- Died: 14 Sep 1948, , Clay County, West Virginia at age 78
- Buried: Wayne Farm Plot, Clay County, West Virginia
James married Mary Davis on 1 Aug 1892 in , Clay County, West Virginia. (Mary Davis was born in 1876 in , , West Virginia and died in , Clay County, West Virginia.)
James next married Vinita Hathaway on 25 May 1907.
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